2004 FDA Science Forum Poster Abstract: K-08

K-08

Dynamics of Bisphenol A Distribution in the Neuroendocrine Tissues
J. C. Hutter¹, M. D. Luu¹, C. S. Kim², ¹CDRH, FDA, Rockville MD, ²CFSAN, FDA, Laurel MD

Bisphenol A (BPA) is a known xenoestrogen with similar properties to 17b-estradiol. BPA is a hydrophobic compound, and this affects the pharmacokinetics both compounds in mammals. In a previous study we measured the distribution of BPA in female F344 rats exposed to oral doses of 0.1, 10, and 100 mg/kg. The results indicated distribution to target neuroendocrine organs (pituitary, brain stem, cerebellum, hippocampus, hypothalamus, frontal cortex, caudate nucleus) at all doses tested. Using these results, we developed a pharmacokinetic model to predict the dynamic uptake and excretion of bisphenol A by various routes of exposure (po, iv, sc, ip). The model was able to simulate the entire time course (48 h) following exposure in rats over the dose range tested. The model indicated that the observed initial rapid uptake was due to the slow kinetics of plasma protein binding. With the exception of the GI tract, the highest uptakes were found in the liver and kidney. BPA was also found to persist in neuroendocrine organs. Binding in plasma and tissues influenced uptake and retention of BPA in target tissues.

2004 FDA Science Forum | FDA Chapter, Sigma Xi | CFSAN | FDA

Last updated on 2004-APR-02 by frf