Leveraging ActivitesGroup Award for Leveraging Activities - 2001 FDA Science Forum

Board B03

STUDIES ON PARAMETERS OF UV RESPONSE IN HUMAN SKIN: A PROGRESS REPORT.
J.Z. Beer1, H.F. Bushar1, D.N. Busick1, D.J. Chwirut1, W.H. Cyr1, M.N. Ediger1, N.T. Lao1, L.S. Matchette1, S.A. Miller1, H. Lopez1, S. Weininger1, B.Z. Zmudzka1, E. Toombs2, H. Jorgensen3, K.S. Korossy4, V.J. Hearing5, N. Kobayashi5, T. Tadokoro5, J.C. van der Leun6, E. Lenderink7, 1CDRH, FDA, Rockville MD, 2CFSAN, FDA, Washington DC, 3Washington Hospital Center, Washington, DC, 4Kensington, MD, 5NCI, NIH, Bethesda MD, 6Utrecht University, Utrecht, The Netherlands, 7Philips Research, Eindhoven, The Netherlands.

We are evaluating the usefulness of non-invasive and biomarker methods for measuring UV responses in human skin. The observations will involve 110 subjects representing different UV sensitivities within six racial/ethnic groups. The non-invasive techniques include two reflectance spectroscopy methods, optical coherence tomography, ultrasound imaging, and two mechanical methods: ballistometry and a suction technique. Shave biopsies are analyzed for DNA damage and repair, and for melanin production and distribution. At the time of writing, data have been collected on 52 subjects. They indicate that, in addition to the visible erythema and pigmentation, UV causes skin changes that are discernible with almost all the techniques examined. Induction of DNA damage following exposure to 1 Minimal Erythema Dose (MED) was readily detectable. Data confirm substantial MED variation within conventional skin types and indicate that racial/ethnic origin is not a significant factor determining individual UV sensitivity.

2001 FDA Science Forum | FDA Chapter, Sigma Xi | CFSAN | FDA
Last updated on 2001-FEB-22 by frf