Allometric Approaches to Clearance (Empirical)

Approach 5

Cl = Clan(in vivo) 7 Clh(hepatocytes)/Clan(hepatocytes)

Approach 6

Clh = a 7 Clan

Approach 7

Clh = Clan 7 Clh(hepatocytes)/Clan(hepatocytes) 7 (Wh/Wan)0.86

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