Absorption & Bioavailability Interspecies Scalability

The greater the ERH , the greater the likelihood that interspecies differences in absorbed dose will be magnified!

Why?

ERH = 0.8 1 - ERH = 0.2

Consider 12.5% reduction in ER

ERH = 0.7 1 - ERH = -.3, a 50% increase in effective dose

Conversely

ERH = 0.2 1 - ERH = 0.8

Consider 50% reduction in ER

ERH = 0.1 1 - ERH = 0.9, a 12.5% increase in effective dose