Neurotoxicity: Ongoing/Planned Research

• Dose/duration/effect/onset -

  • FDA/NCTR - Ancillary studies with 2-year rodent bioassays to assess cumulative damage from low-level dietary exposures?

• Mechanisms -

  • Academic - Nerve terminal damage, axonal transport, key proteins, etc.
  • NIEHS - CYP 2E1 null mouse, antioxidant, Phase II enzyme inhibitor
  • NIOSH - Markers in exposed workers

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