Kinetics, Metabolism & Modes of Action: Ongoing/Planned Research

• Critical events/dose metrics/MoA -

  • FDA/NCTR - Linked to NTP bioassay
  • NIEHS - CYP 2E1 null mouse studies

• Metabolism/kinetics in humans -

  • Several groups - RTI, CDC/NHANES, Stockholm U., Kaiserslautern U., others

• PBPK models -

  • Kirman et al. (2003) - Rat model; others?

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