Safety/risk assessment - Effective dose, Exposure, ADI

• Lowest neurotoxic dose in rats

  • 1000 mcg per kg body weight
  • No effect seen at 200 mcg/kg

• WHO/FAO - typical dietary intake

  • 0.3-0.8 mcg/kg body weight

• FDA Acceptable Daily Intake for food contact decisions

  • 1000 fold uncertainty factor
  • 0.2 mcg/kg body weight