4. Plans for Reproductive/ developmental effects study

• FDA

  • Genotoxicity endpoints in NTP study, including initial subchronic studies (under development)
  • Workshop for germ cell mutagen risk assessment

• NIOSH worker studies

  • NIEHS collaboration for reproductive/genotox

• NIEHS evaluation of CYP2E1 knockout mice for dominant lethal effect

• Expert review panel by National Toxicology Program (NTP) Center for the Evaluation of Risks to Human Reproduction (CERHR)