4. Reproductive/ developmental effects (other than neurotoxicity)

• Decreased body weight, but no structural malformations

• Reduced litter sizes (5000 mcg/kg treatment of males)

• Germ cell mutagen in animals at high, injected doses

• Genetic effects in mice (injection >40,000 mcg/kg)

  • Specific-locus mutations
  • Heritable or reciprocal transformations
  • Unscheduled DNA synthesis in spermatids,chromosomal aberrations or micronuclei frequency in spermatogenic cells