1. Toxicokinetics data needs

• Bioavailability of acrylamide from food

• Dose-response for toxicity, disposition, and binding

  • Dose metrics, critical events, mode of action

• DNA to hemoglobin adduct relationship

• DNA and protein binding as a marker of toxicity and risk

  • Significant nuclear protiens

• Toxicokinetics of acrylamide in humans

• Risk factors for susceptibility